Can You Make A Weapon Based On Specific Genetic Makeup

Effigy i: Gram stained cerebrospinal fluid showing gram-positive anthrax baccilli (majestic rods). Courtesy of Wikimedia.

Genome sequencing has given ascent to a new generation of genetically engineered bioweapons carrying the potential to change the nature of mod warfare and defence force.

Introduction

Biological weapons are designed to spread disease among people, plants, and animals through the introduction of toxins and microorganisms such as viruses and bacteria. The method through which a biological weapon is deployed depends on the agent itself, its training, its immovability, and the route of infection. Attackers may disperse these agents through aerosols or nutrient and h2o supplies (1).

Although bioweapons have been used in war for many centuries, a recent surge in genetic understanding, as well as a rapid growth in computational ability, has immune genetic applied science to play a larger role in the development of new bioweapons. In the bioweapon industry, genetic engineering can be used to manipulate genes to create new pathogenic characteristics aimed at enhancing the efficacy of the weapon through increased survivability, infectivity, virulence, and drug resistance (two). While the positive societal implications of improved biotechnology are credible, the "black biology" of bioweapon evolution may be "one of the gravest threats nosotros volition face" (2).

Limits of Past Bioweapons

Prior to contempo advances in genetic engineering, bioweapons were exclusively natural pathogens. Agents must fulfill numerous prerequisites to be considered effective military bioweapons, and most naturally occurring pathogens are ill suited for this purpose (3). Kickoff, bioweapons must be produced in large quantities. A pathogen can be obtained from the natural surroundings if plenty tin be collected to permit purification and testing of its properties. Otherwise, pathogens could be produced in a microbiology laboratory or banking company, a process which is limited past pathogen accessibility and the safety with which the pathogens can be handled in facilities. To replicate viruses and some bacteria, living cells are required. The growth of large quantities of an agent tin can be limited by equipment, infinite, and the wellness risks associated with the treatment of hazardous germs (1). In addition to big-scale production, effective bioweapons must act rapidly, exist environmentally robust, and their furnishings must exist treatable for those who are implementing the bioweapon (3).

Recent Advances

As researchers continue to transition from the era of Dna sequencing into the era of DNA synthesis, information technology may soon go feasible to synthesize any virus whose Dna sequence is known (four). This was first demonstrated in 2001 when Dr. Eckard Wimmer re-created the poliovirus and once again in 2005 when Dr. Jeffrey Taubenberger and Terrence Tumpey re-created the 1918 influenza virus (one). The progress of Deoxyribonucleic acid synthesis technology volition besides let for the cosmos of novel pathogens. According to biological warfare expert Dr. Steven Block, genetically engineered pathogens "could be made safer to handle, easier to distribute, capable of ethnic specificity, or be made to crusade higher mortality rates" (2).

The growing accessibility of DNA synthesis capabilities, computational ability, and information ways that a growing number of people will have the capacity to produce bioweapons. Scientists have been able to transform the 4 letters of DNA—A (adenine), C (cytosine), G (guanine), and T (thymine)—into the ones and zeroes of binary lawmaking. This transformation makes genetic engineering a matter of electronic manipulation, which decreases the cost of the technique (4). Co-ordinate to sometime Secretary of State Hillary Clinton, "the emerging gene synthesis industry is making genetic material more than widely available […] A rough but effective terrorist weapon tin exist made using a small sample of any number of widely bachelor pathogens, inexpensive equipment, and college-level chemical science and biology." (5)

Figure 2: Virus responsible for poliomyelitus (picornavirus). Through improved vaccination efforts, polio will soon exist eradicated from the globe. Courtesy of Sanofy Pasteur.

Techniques to Enhance Efficacy of Bioweapons

Scientists and genetic engineers are considering several techniques to increase the efficacy of pathogens in warfare.

1. Binary Biological Weapons

This technique involves inserting plasmids, small bacterial DNA fragments, into the DNA of other leaner in order to increase virulence or other pathogenic properties within the host leaner (ii).

2. Designer Genes

According to the European Bioinformatics Institute, as of Dec 2012, scientists had sequenced the genomes of 3139 viruses, 1016 plasmids, and 2167 bacteria, some of which are published on the internet and are therefore accessible to the public (6). With complete genomes bachelor and the aforementioned advances in gene synthesis, scientists volition before long be able to design pathogens by creating synthetic genes, synthetic viruses, and possibly entirely new organisms (2).

3. Gene Therapy

Cistron therapy involves repairing or replacing a gene of an organism, permanently changing its genetic composition. By replacing existing genes with harmful genes, this technique tin be used to manufacture bioweapons (2).

4. Stealth Viruses

Stealth viruses are viral infections that enter cells and remain dormant for an extended amount of time until triggered externally to cause disease. In the context of warfare, these viruses could be spread to a large population, and activation could either be delayed or used equally a threat for blackmail (two).

five. Host-Swapping Diseases

Much like the naturally occurring West Nile and Ebola viruses, fauna viruses could potentially be genetically modified and developed to infect humans as a potent biowarfare tactic (ii).

6. Designer Diseases

Biotechnology may be used to manipulate cellular mechanisms to cause disease. For example, an agent could be designed to induce cells to multiply uncontrollably, every bit in cancer, or to initiate apoptosis, programmed cell death (2).

7. Personalized Bioweapons

In coming years it may be conceivable to design a pathogen that targets a specific person's genome. This agent may spread through populations showing minimal or no symptoms, yet it would be fatal to the intended target (4).

Biodefense

In addition to creating bioweapons, the emerging tools of genetic knowledge and biological technology may be used as a means of defense against these weapons.

1. Human Genome Literacy

As scientific research continues to reveal the functions of specific genes and how genetic components affect disease in humans, vaccines and drugs can be designed to combat particular pathogens based on analysis of their detail molecular upshot on the homo cell (2).

two. Immune System Enhancement

In addition to enabling more effective drug development, man genome literacy allows for a better understanding of the allowed system. Thus, genetic engineering can be used to enhance human allowed response to pathogens. Equally an example, Dr. Ken Alibek is conducting cellular research in pursuit of protection against the bioweapon anthrax (2).

3. Viral and Bacterial Genome Literacy

Decoding the genomes of viruses and bacteria will lead to molecular explanations backside virulence and drug resistance. With this information, leaner can exist engineered to produce bioregulators against pathogens. For example, Xoma Corporation has patented a bactericidal/permeability-increasing (BPI) protein, made from genes inserted into bacterial DNA, which reverses the resistance feature of particular bacteria against some popular antibiotics (2).

4. Efficient Bio-Amanuensis Detection and Identification Equipment

Because the capability of comparison genomes using DNA assays has already been acquired, such technology may be developed to place pathogens using information from bacterial and viral genomes. Such a detector could be used to identify the composition of bioweapons based on their genomes, reducing present-day delays in resultant treatment and/or preventive measures (ii).

five. New Vaccines

Current scientific research projects involve genetic manipulation of viruses to create vaccines that provide immunity confronting multiple diseases with a single treatment (2).

vi. New Antibiotics and Antiviral Drugs

Currently, antibiotic drugs target Dna synthesis, protein synthesis, and cell-wall synthesis processes in bacterial cells. With an increased understanding of microbial genomes, other proteins essential to bacterial viability can be targeted to create new classes of antibiotics. Somewhen, broad-spectrum, rather than protein-specific, anti-microbial drugs may be adult (ii).

Future of Warfare

"The revolution in molecular biological science and biotechnology tin be considered as a potential Revolution of Military Affairs (RMA)," states Colonel Michael Ainscough, Dr., MPH (two). According to Andrew Krepinevich, who originally coined the term RMA, "technological advancement, incorporation of this new engineering science into military systems, military operational advancement, and organizational adaptation in a manner that fundamentally alters the character and conduct of disharmonize" are the four components that make up an RMA. For instance, the Gulf War has been classified as the offset of the space information warfare RMA. "From the technological advances in biotechnology, biowarfare with genetically engineered pathogens may plant a future such RMA," says Ainscough (2).

In improver, the exponential increase in computational power combined with the accessibility of genetic data and biological tools to the general public and lack of governmental regulation raise concerns about the threat of biowarfare arising from exterior the armed services (vii). The Usa government has cited the efforts of terrorist networks, such as al Qaida, to recruit scientists capable of creating bioweapons equally a national security concern and "has urged countries to be more than open about their efforts to clamp down on the threat of bioweapons" (v).

Despite these efforts, biological inquiry that tin potentially lead to bioweapon development is "far more international, far more spread out, and far more diverse than nuclear science […] researchers communicate much more rapidly with i another by ways that no authorities can control […] this was not truthful in the nuclear era," co-ordinate to David Kay, sometime chief U.South. weapons inspector in Iraq (vii). Kay is "extraordinarily pessimistic that we [the United States] will accept any of the necessary steps to avoid the threat of bioweapons absent their first actual employ" (seven).

"There are those who say: 'the Outset World War was chemical; the Second World War was nuclear; and that the Third Globe State of war – God prevent – will be biological'" (2).

Contact Mackenzie Foley at Mackenzie.A.Foley.sixteen@dartmouth.edu

References

1. Federation of American Scientists, Introduction to Biological Weapons (2011). Available at http://www.fas.org/programs/bio/bwintro.html (28 Dec 2012).

ii. M. Ainscough, Side by side Generation Bioweapons: Genetic Engineering and Biowarfare (April 2002). Bachelor at http://www.au.af.mil/au/awc/awcgate/cpc-pubs/biostorm/ainscough.pdf (28 December 2012).

3. J. van Aken, E. Hammond, EMBO Rep. four, S57–S60 (2003).

4. A. Hessel, M. Goodman, S. Kotler, Hacking the President's DNA. The Atlantic (Nov 2012). Available at http://world wide web.theatlantic.com/magazine/archive/2012/11/hacking-the-presidents-dna/309147/?single_page=true (28 Dec 2012).

5. Advances in Genetics Could Create Deadly Biological Weapons, Clinton Warns (07 July 2011). Bachelor at http://www.breakingnews.ie/globe/advances-in-genetics-could-create-mortiferous-biological-weapons-clinton-warns-531347.html (28 December 2012).

6. European Bioinformatics Institute, Access to Completed Genomes (17 Dec 2012). Available at http://www.ebi.air conditioning.united kingdom/genomes/index.html (28 December 2012).

vii. D. Kay, Genetically Engineered Bioweapons (2003). Available at http://world wide web.aaas.org/spp/yearbook/2003/ch17.pdf (28 Dec 2012).

Can You Make A Weapon Based On Specific Genetic Makeup,

Source: https://sites.dartmouth.edu/dujs/2013/03/10/genetically-engineered-bioweapons-a-new-breed-of-weapons-for-modern-warfare/

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